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Plasmon-Based Colorimetric Nanosensors for Ultrasensitive Molecular Diagnostics
1State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University , Hangzhou 310027, China.
ACS Sensors
|July 29, 2017
Summary
Plasmonic nanoparticles enhance colorimetric detection for ultrasensitive molecular diagnostics. This review covers nanosensors based on nanoparticle assembly and growth/etching for advanced point-of-care applications.
Area of Science:
- Nanotechnology
- Analytical Chemistry
- Biomedical Engineering
Background:
- Colorimetric detection is crucial for point-of-care diagnostics.
- Plasmonic nanomaterials offer enhanced sensitivity in biosensing.
- Existing methods require improvements in specificity and sensitivity.
Purpose of the Study:
- To review recent advancements in plasmonic nanoparticle-based colorimetric nanosensors.
- To classify nanosensors based on their signal generation mechanisms.
- To highlight applications in ultrasensitive molecular diagnostics.
Main Methods:
- Review of interparticle distance-dependent assays (assembly/aggregation).
- Review of size/morphology-dependent assays (growth/etching).
- Focus on signal generation and amplification strategies.
Main Results:
- Plasmonic nanosensors achieve ultrasensitive molecular detection.
- Two main categories of colorimetric assays identified.
- Demonstrated improved sensitivity in various biosensing applications.
Conclusions:
- Plasmonic nanoparticles are key to advanced colorimetric nanosensors.
- Further research can address current challenges in the field.
- Future perspectives for ultrasensitive diagnostics are discussed.
