Related Experiment Video
Updated: Feb 25, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
Published on: September 17, 2020
Non-genomic transmission of longevity between generations: potential mechanisms and evidence across species
Alexander M Vaiserman1, Alexander K Koliada2, Randy L Jirtle3,4
1D.F. Chebotarev Institute of Gerontology, NAMS, Vyshgorodskaya st. 67, Kiev, 04114, Ukraine. vaiserman23@gmail.com.
Abstract:
Accumulating animal and human data indicate that environmental exposures experienced during sensitive developmental periods may strongly influence risk of adult disease. Moreover, the effects triggered by developmental environmental cues can be transgenerationally transmitted, potentially affecting offspring health outcomes. Increasing evidence suggests a central role of epigenetic mechanisms (heritable alterations in gene expression occurring without changes in underlying DNA sequence) in mediating these effects. This review summarizes the findings from animal models, including worms, insects, and rodents, and also from human studies, indicating that lifespan and longevity-associated characteristics can be transmitted across generations via non-genetic factors.
Related Concept Videos
Types of Genetic Transfer Between Organisms
Types of Genetic Transfer Between Organisms
Multi-species Conserved Sequences
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
Mutation, Gene Flow, and Genetic Drift
Gene Flow
The Evidence for Evolution

