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Updated: Feb 25, 2026

Ultrasonic-Assisted Extraction of Cannabidiolic Acid from Cannabis Biomass
Published on: May 27, 2022
New Methods for the Synthesis of Cannabidiol Derivatives
Ana Lago-Fernandez1, Vanessa Redondo1, Laura Hernandez-Folgado1
1Instituto de Química Médica, Consejo Superior de Investigaciones Científicas, Unidad Asociada I+D+i IQM/Universidad Rey Juan Carlos (URJC), Madrid, Spain.
Abstract:
Cannabidiol (CBD) is one of the most abundant components isolated from Cannabis sativa. However, CBD is a nonpsychotropic phytocannabinoid. In the last decade, there has been a growing interest in its therapeutic effects. This is why this natural product represents a lead structure for the development of new cannabinoid compounds. Even though chemistry of CBD has been explored for more than 30 years, the synthesis of only a few derivatives has been described. This chapter first reviews the synthetic methods for the preparation of CBD and derivatives. Then, it describes procedures for the synthesis of N-heterocyclic derivatives of CBD with, in particular, the preparation and structural characterization of 5-alkyl-2-(1H-pyrazol-3-yl)benzene-1,3-diol.
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Ethers from Alcohols: Alcohol Dehydration and Williamson Ether Synthesis
Ethers can be prepared from organic compounds by various methods. Some of them are discussed below,
Preparation of Ethers by Alcohol Dehydration
In this method, in the presence of protic acids, alcohol dehydrates to produce alkenes and ethers under different conditions. For example, in the presence of sulphuric acid, dehydration of ethanol at 413 K yields ethoxyethane, whereas it yields ethene at 443 K.