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Updated: Feb 25, 2026

Cellular Redox Profiling Using High-content Microscopy
Published on: May 14, 2017
Mitochondria targeting by environmental stressors: Implications for redox cellular signaling
Chuck Blajszczak1, Marcelo G Bonini1
1Departments of Medicine and Pathology, University of Illinois College of Medicine at Chicago, IL, USA.
Abstract:
Mitochondria are cellular powerhouses as well as metabolic and signaling hubs regulating diverse cellular functions, from basic physiology to phenotypic fate determination. It is widely accepted that reactive oxygen species (ROS) generated in mitochondria participate in the regulation of cellular signaling, and that some mitochondria chronically operate at a high ROS baseline. However, it is not completely understood how mitochondria adapt to persistently high ROS states and to environmental stressors that disturb the redox balance. Here we will review some of the current concepts regarding how mitochondria resist oxidative damage, how they are replaced when excessive oxidative damage compromises function, and the effect of environmental toxicants (i.e. heavy metals) on the regulation of mitochondrial ROS (mtROS) production and subsequent impact.
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