Brittle fracture propensity measurements on 'tablet-sized' cylindrical compacts

Area of Science:

• Pharmaceutical sciences
• Materials science

Background:

• The brittle fracture propensity test was initially developed for large, square compacts.
• Tableting processes involve specific strain rates and conditions.

Purpose of the Study:

• To adapt the brittle fracture propensity test for tablet-sized compacts.
• To measure the brittle fracture propensity (BFP) index under tableting-relevant conditions.

Main Methods:

• Modification and extension of the brittle fracture propensity test for smaller dimensions.
• Evaluation of BFP indices using microcrystalline cellulose, Tablettose, and heavy magnesium carbonate.
• Testing at punch velocities of 3.33 mm s-1 and 200 mm s-1.

Main Results:

• The modified test successfully measured BFP indices for tablet-sized compacts.
• Results obtained at relevant tableting strain rates were consistent with previous studies.
• BFP indices for the tested materials were successfully determined.

Conclusions:

• The adapted brittle fracture propensity test is suitable for evaluating tablet-sized materials.
• The modified test provides reliable BFP index measurements under tableting conditions.
• This method facilitates the study of material behavior during pharmaceutical tablet manufacturing.