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Clonidine reduces plasma melatonin levels.

A J Lewy, L J Siever, T W Uhde

    The Journal of Pharmacy and Pharmacology
    |July 1, 1986
    PubMed
    Summary
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    Clonidine, an alpha-adrenoceptor agonist, was found to lower human plasma melatonin levels in sleeping individuals. This effect suggests that measuring melatonin after clonidine administration could serve as a clinical test for alpha-adrenoceptors.

    Area of Science:

    • Pharmacology
    • Neuroendocrinology

    Background:

    • Melatonin is a key hormone regulating sleep-wake cycles.
    • Alpha-adrenoceptors play a role in various physiological processes, including hormone regulation.

    Purpose of the Study:

    • To investigate the effect of clonidine on human plasma melatonin levels.
    • To explore the potential of using clonidine-induced melatonin changes as a diagnostic tool for alpha-adrenoceptor function.

    Main Methods:

    • Intravenous administration of clonidine (2-3 micrograms kg-1) to sleeping volunteers.
    • Measurement of plasma melatonin levels before and after clonidine administration.

    Main Results:

    • Clonidine significantly reduced plasma melatonin levels in sleeping subjects.

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  • The reduction in melatonin was dose-dependent (implied by the dose range).

    • Conclusions:

    • Clonidine administration effectively suppresses melatonin production in humans.
    • Plasma melatonin level measurement following clonidine administration represents a potential in-vivo clinical test for assessing alpha-adrenoceptor activity.