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A pilot study demonstrating the altered gut microbiota functionality in stable adults with Cystic Fibrosis
F Fouhy1, N J Ronan2,3, O O'Sullivan1,4
1Teagasc Food Research Centre, Moorepark, Fermoy, Co. Cork, Ireland.
Scientific Reports
|July 29, 2017
Summary
Cystic Fibrosis (CF) alters gut microbiota functionality, impacting lipid and xenobiotic metabolism. This study found significant differences in adult CF patients compared to controls, highlighting the need for further research.
Area of Science:
- Microbiology
- Gastroenterology
- Metabolomics
Background:
- Cystic Fibrosis (CF) and its treatments significantly alter gut microbiota composition.
- The functional consequences of these microbiota alterations in CF patients remain largely uncharacterized.
Purpose of the Study:
- To investigate measurable changes in gut microbiota functionality in adult CF patients compared to healthy controls.
- To establish a proof-of-principle for functional analysis of the CF gut microbiome.
Main Methods:
- Faecal samples were collected from six adult CF patients and six non-CF controls.
- Shotgun metagenomic sequencing was performed on extracted DNA.
- Metabolomic analysis utilized gas chromatography-mass spectrometry on faecal water.
Main Results:
- Gut microbiota composition differed significantly, with increased Firmicutes and decreased Bacteroidetes in CF patients.
- Altered functionality was observed, including higher pathway abundances in lipid and xenobiotic metabolism in CF patients.
- Significant differences in fecal metabolites were detected between CF patients and controls.
Conclusions:
- Measurable changes in gut microbiota functionality are evident in adult CF patients.
- These findings support the need for larger studies to further explore gut microbiome function in Cystic Fibrosis.
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