Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.5K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.5K
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

62
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
62
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

59
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
59
Allergic Reactions02:06

Allergic Reactions

32.6K
Overview
32.6K
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

1.5K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.5K
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

72
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
72

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinctive Reactivity to the C-terminal Epitope of BP180 Characterizes Immune Checkpoint Inhibitor-associated Bullous Pemphigoid, and an ELISA Based on the BP180 Ectodomain Enables Prompt Diagnosis in a Subset of Patients.

Acta dermato-venereologica·2026
Same author

<i>Letter:</i> Real-Life Improvement in Quality of Life With Delgocitinib in Chronic Hand Eczema.

Dermatitis : contact, atopic, occupational, drug·2026
Same author

Meta-inflammation in Hidradenitis suppurativa: from pathogenic evidence to therapeutic approaches.

Frontiers in immunology·2026
Same author

Beyond Psoriasis Area and Severity Index and Body Surface Area: An Italian Delphi Consensus on the Definition of Moderate Psoriasis.

Dermatology and therapy·2026
Same author

Cutaneous Crohn of the Genital Area Mimicking Hidradenitis Suppurativa in a Patient With Quiescent Intestinal Disease.

International journal of dermatology·2026
Same author

Tinea barbae following ruxolitinib cream application in a vitiligo patient: a case report.

Frontiers in medicine·2026

Related Experiment Video

Updated: Feb 25, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.7K

Chronic urticaria: a focus on pathogenesis.

Riccardo Asero1, Alberto Tedeschi2, Angelo Valerio Marzano3

  • 1Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano (Milano), Italy.

F1000Research
|July 29, 2017
PubMed
Summary

Chronic urticaria involves wheals and angioedema lasting over six weeks. Research suggests immunity, inflammation, and coagulation systems play roles in its complex pathogenesis.

Keywords:
Chronic UritcariaOmalizumabautologous serum skin testwheals

More Related Videos

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

10.9K
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

3.6K

Related Experiment Videos

Last Updated: Feb 25, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.7K
Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

10.9K
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

3.6K

Area of Science:

  • Dermatology
  • Immunology
  • Pathophysiology

Background:

  • Chronic urticaria (CU) is a common condition characterized by wheals and angioedema for over six weeks.
  • CU significantly impacts patients' quality of life and presents diagnostic challenges.
  • The exact causes of chronic urticaria remain unclear, but involve complex biological pathways.

Purpose of the Study:

  • To review current findings on the pathogenesis of chronic urticaria.
  • To elucidate the roles of various biological systems in CU development.

Main Methods:

  • Literature review of recent studies on chronic urticaria.
  • Analysis of evidence linking immune, inflammatory, and coagulation pathways to CU.

Main Results:

  • Growing evidence implicates interconnected biological systems in CU.
  • Mast cell and basophil degranulation are key events in wheal formation.
  • Immunity, inflammation, and coagulation pathways are increasingly recognized as contributors.

Conclusions:

  • The pathogenesis of chronic urticaria is multifactorial, involving immune, inflammatory, and coagulation systems.
  • Further research is needed to fully understand these complex interactions and develop targeted therapies.