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Tuncay Sahin1, Alexandre Brygo, Emmanuel Delaporte

  • 1Universitäre Abteilung für Kieferchirurgie und Stomatologie, Hôpital Roger Salengro, CHU de Lille, Frankreich.

Swiss Dental Journal
|July 29, 2017
PubMed
Summary

Oral manifestations like ulcers and cobblestoning can be early signs of Crohn's disease (CD), often appearing years before intestinal symptoms. Prompt diagnosis through oral examination aids in timely treatment and improved quality of life.

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Area of Science:

  • Gastroenterology
  • Oral Medicine
  • Dermatology

Background:

  • Crohn's disease (CD) is a chronic inflammatory bowel disease.
  • Oral manifestations of CD are often overlooked.
  • Early orofacial signs can precede gastrointestinal symptoms.

Purpose of the Study:

  • To identify and report early orofacial presentations of Crohn's disease.
  • To highlight the diagnostic value of oral lesions in CD.
  • To analyze the time to diagnosis and treatment in CD patients with oral findings.

Main Methods:

  • Retrospective analysis of nine patients diagnosed with CD between 2008 and 2015.
  • Review of clinical oral examinations, including specific lesions like ulcerative buccal lesions, cobblestoning, mucosal tags, and perioral erythema.
  • Correlation of oral findings with subsequent intestinal diagnosis and treatment.

Main Results:

  • Key oral findings included linear ulcerative buccal lesions, cobblestoning, mucosal tags, and perioral erythema.
  • In 45% of patients, oral biopsies showed lesions suggestive of CD before intestinal symptoms.
  • The mean time from initial oral presentation to CD diagnosis was 14 months.
  • 89% of patients received immunomodulatory therapy (azathioprine, infliximab, adalimumab).

Conclusions:

  • Oropharyngeal lesions can serve as crucial early indicators for Crohn's disease diagnosis.
  • Timely diagnosis facilitated by oral examination can lead to earlier initiation of specific therapies.
  • Early intervention is essential for managing disease severity and enhancing patient quality of life.
Keywords:
Morbus Crohnorofaziale Granulomatose

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