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Published on: June 10, 2013
Cannabinoid system of dorsomedial telencephalon modulates behavioral responses to noxious stimulation in the fish
Carla Patricia Bejo Wolkers1, Leda Menescal-de-Oliveira2, Anette Hoffmann2
1Faculty of Integrated Sciences of Pontal (FACIP), Federal University of Uberlândia, UFU, Ituiutaba, MG, Brazil; Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, 3900 Bandeirantes Avenue, Ribeirão Preto, SP, Brazil.
Abstract:
Fish dorsomedial telencephalon has been considered a pallial region homologous to mammals amygdala, being considered a possible substrate for nociception modulation in this animal group. The present study aimed to evaluate the participation of the cannabinoid system of Dm telencephalon on nociception modulation in the fish Leporinus macrocephalus. We demonstrated that cannabidiol microinjection in Dm telecephalon inhibits the behavioral nociceptive response to the subcutaneous injection of 3% formaldehyde, and this antinociception is blocked by previous treatment with AM251 microinjection. Furthermore, AM251 microinjection in Dm prior to restraint stress also blockades the stress-induced antinociception. These results reinforce the hypothesis that this pallial telencephalic structure has a pivotal role in nociception modulation in fish.
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