Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Viral Replication: Lysogenic Cycle01:16

Viral Replication: Lysogenic Cycle

1.9K
The lysogenic cycle is a crucial viral replication strategy that allows bacteriophages to persist within host cells without immediately destroying them. This process is primarily observed in temperate phages, such as bacteriophage lambda (λ), which infects Escherichia coli. The cycle allows the viral genome to persist across bacterial generations while keeping host cells viable.Integration of the Viral GenomeUpon infection, bacteriophage lambda attaches to the bacterial surface and injects...
1.9K
Lysogenic Cycle of Bacteriophages00:43

Lysogenic Cycle of Bacteriophages

68.2K
In contrast to the lytic cycle, phages infecting bacteria via the lysogenic cycle do not immediately kill their host cell. Instead, they combine their genome with the host genome, allowing the bacteria to replicate the phage DNA along with the bacterial genome. The incorporated copy of the phage genome is called the prophage. Some prophages can re-activate and enter the lytic cycle. This often occurs in response to a perturbation, such as DNA damage, but can also transpire in the absence of...
68.2K
DNA Bacteriophages01:26

DNA Bacteriophages

1.2K
Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...
1.2K
Lytic Cycle of Bacteriophages01:30

Lytic Cycle of Bacteriophages

78.5K
Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...
78.5K
Transduction01:16

Transduction

2.0K
Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
2.0K
Viral Replication: Lytic Cycle01:20

Viral Replication: Lytic Cycle

2.0K
Bacteriophages, or phages, are viruses that specifically infect bacteria. Among them, T-even bacteriophages, such as T4, exhibit a well-characterized lytic replication cycle in Escherichia coli (E. coli). This process ensures the rapid proliferation of the virus while ultimately leading to the destruction of the bacterial host.Attachment and DNA InjectionThe infection process begins with the recognition and binding of the T4 phage to the E. coli cell surface. Tail fibers of the phage...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantitative Aspect of <i>Bacillus subtilis</i> σ<sup>B</sup> Regulatory Network on a Proteome Level-A Computational Simulation.

Biology·2024
Same author

Whole proteome analysis of germinating and outgrowing Bacillus subtilis 168.

Proteomics·2024
Same author

σ<sup>E</sup> of Streptomyces coelicolor can function both as a direct activator or repressor of transcription.

Communications biology·2024
Same author

Quantitative Aspect of <i>Bacillus subtilis</i> σB Regulatory Network-A Computational Simulation.

Biology·2022
Same author

Recommendations for connecting molecular sequence and biodiversity research infrastructures through ELIXIR.

F1000Research·2022
Same author

rboAnalyzer webserver: web service for non-coding RNA characterization from NCBI BLAST output.

Bioinformatics (Oxford, England)·2021

Related Experiment Video

Updated: Feb 25, 2026

Following Cell-fate in E. coli After Infection by Phage Lambda
06:10

Following Cell-fate in E. coli After Infection by Phage Lambda

Published on: October 14, 2011

24.3K

Lambda phage genetic switch as a system with critical behaviour.

Jiri Vohradsky1

  • 1Laboratory of Bioinformatics, Institute of Microbiology, ASCR, Videnska 1083, 14220 Prague, Czech Republic.

Journal of Theoretical Biology
|July 30, 2017
PubMed
Summary
This summary is machine-generated.

This study explores critical behavior in cellular systems using the lambda phage genetic network. Computational simulations demonstrate this critical behavior in gene expression, offering new insights into biological control mechanisms.

Keywords:
Computational simulationCritical behaviourGenetic networksPhage lambda

More Related Videos

Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics
09:23

Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics

Published on: January 5, 2024

2.6K
Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
09:40

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

12.9K

Related Experiment Videos

Last Updated: Feb 25, 2026

Following Cell-fate in E. coli After Infection by Phage Lambda
06:10

Following Cell-fate in E. coli After Infection by Phage Lambda

Published on: October 14, 2011

24.3K
Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics
09:23

Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics

Published on: January 5, 2024

2.6K
Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
09:40

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

12.9K

Area of Science:

  • Molecular Biology
  • Systems Biology
  • Computational Biology

Background:

  • Critical behavior is observed across diverse scientific fields.
  • The role of critical behavior in cellular control systems remains underexplored.
  • Lambda phage gene expression in Escherichia coli presents a potential system for studying critical behavior.

Purpose of the Study:

  • To computationally simulate the transcriptional control of lambda phage genes.
  • To demonstrate critical behavior within the lambda phage genetic network.
  • To investigate the lytic-lysogenic switch mechanism.

Main Methods:

  • Development of a computational model for lambda phage transcriptional control.
  • Simulation of temporal gene expression changes.
  • Analysis of gene expression patterns to identify critical behavior.

Main Results:

  • The study successfully simulated gene expression dynamics in the lambda phage system.
  • Evidence of critical behavior was demonstrated through computational analysis.
  • The model captured the complex interplay of genes governing the lytic-lysogenic switch.

Conclusions:

  • The lambda phage genetic network exhibits critical behavior.
  • Computational modeling is a viable approach to study critical phenomena in biological systems.
  • Further exploration of critical behavior in cell control systems is warranted.