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Updated: Feb 25, 2026

A High-throughput Calcium-flux Assay to Study NMDA-receptors with Sensitivity to Glycine/D-serine and Glutamate
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Discovery of orally bioavailable cyclohexanol-based NR2B-selective NMDA receptor antagonists with analgesic activity

Kosuke Anan1, Moriyasu Masui1, Shinichiro Hara1

  • 1Medicinal Chemistry Research Laboratory, Shionogi & Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan.

Bioorganic & Medicinal Chemistry Letters
|July 30, 2017
PubMed

Keywords:
Analgesic activityBioisosteric replacementNMDA receptor antagonistScaffold hopping

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