The role of the tumour microenvironment in immunotherapy

Stephan Gasser1,2, Lina H K Lim3, Florence S G Cheung4

  • 1Roche Pharma Research and Early DevelopmentRoche Innovation Center Zurich, Roche Glycart AG, Schlieren, Switzerland stgasser1@yahoo.com flozc17@hotmail.com.

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The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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