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Updated: Feb 25, 2026

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
Published on: April 28, 2021
It Takes Two: One Resects, One Reconstructs
Shabnam Ghazizadeh1, Edward C Kuan1, Jon Mallen-St Clair2
1Department of Head and Neck Surgery, University of California, Los Angeles Medical Center, 10833 Le Conte Avenue, CHS 62-132, Los Angeles, CA 90095, USA.
Abstract:
Care of patients with advanced head and neck cancer is a multidisciplinary effort through all phases of care. Head and neck cancer surgery involves balancing oncologic control, functional preservation, and aesthetics. Given the advances in free tissue reconstruction, the majority of defects can be reconstructed using free tissue transfer flaps. A 2-team approach allows for early, continual communication and meticulous operative planning. Operations can be combined into a single effort. This approach maximizes efficiency and enables multidisciplinary collaboration for comprehensive surgical treatment. We present our experience and an outline of how responsibilities between the ablative and reconstructive teams are shared.
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