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Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Abnormal Proliferation02:23

Abnormal Proliferation

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Mismatch Repair01:20

Mismatch Repair

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Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
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Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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Related Experiment Video

Updated: Feb 25, 2026

Establishing a Competing Risk Regression Nomogram Model for Survival Data
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Establishing a Competing Risk Regression Nomogram Model for Survival Data

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Survivorship: Morbidity, Mortality, Malignancy.

Kelly M Malloy1, Anna M Pou2

  • 1Department of Otolaryngology-Head and Neck Surgery, University of Michigan, 1904 Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI 48019, USA.

Otolaryngologic Clinics of North America
|July 31, 2017
PubMed
Summary
This summary is machine-generated.

Cancer survivorship includes all aspects of living with cancer, from diagnosis through the end of life. This definition now importantly includes caregivers and family members in the cancer survivorship experience.

Keywords:
GuidelinesMorbidityPalliative careSurveillanceSurvivorship

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Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
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Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

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Related Experiment Videos

Last Updated: Feb 25, 2026

Establishing a Competing Risk Regression Nomogram Model for Survival Data
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Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
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Area of Science:

  • Oncology
  • Public Health
  • Patient Advocacy

Background:

  • Cancer survivorship is a critical phase in cancer care, extending beyond active treatment.
  • Understanding the multifaceted nature of survivorship is essential for comprehensive patient support.
  • The traditional focus on the patient often overlooks the broader impact on the support system.

Purpose of the Study:

  • To define the scope of cancer survivorship.
  • To emphasize the inclusion of caregivers and family in the survivorship paradigm.
  • To promote a holistic understanding of the cancer journey.

Main Methods:

  • Literature review and synthesis of existing definitions.
  • Analysis of the National Cancer Institute's Office of Cancer Survivorship guidelines.
  • Conceptual framework development for cancer survivorship.

Main Results:

  • Survivorship is defined as the comprehensive experience from cancer diagnosis until death.
  • This experience encompasses therapeutic, psychosocial, functional, and financial aspects.
  • The definition is expanded to explicitly include caregivers, family, and friends.

Conclusions:

  • A broadened definition of cancer survivorship is crucial for holistic care.
  • Recognizing the impact on caregivers and family is vital for effective support systems.
  • This inclusive approach enhances the understanding and management of the cancer journey.