Ketamine changes the local resting-state functional properties of anesthetized-monkey brain
Jia-Sheng Rao1, Zuxiang Liu2, Can Zhao1
1Beijing Key Laboratory for Biomaterials and Neural Regeneration, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
Magnetic Resonance Imaging
|July 31, 2017
Summary
Single-dose ketamine alters brain activity. Resting-state functional magnetic resonance imaging (rs-fMRI) showed changes in fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo) in key brain regions of rhesus monkeys.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Ketamine is a known anesthetic with recreational use linked to psychosis and cognitive issues.
- Previous research explored ketamine's acute and chronic effects on brain circuits.
- The impact of a single ketamine dose on local resting-state brain function was not well understood.
Purpose of the Study:
- To investigate the effects of a single ketamine dose on local intrinsic brain properties.
- To assess ketamine's influence on resting-state functional magnetic resonance imaging (rs-fMRI) metrics.
Main Methods:
- Seven adult rhesus monkeys were scanned using rs-fMRI.
- Fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo) were measured before and after ketamine administration.
- Paired comparisons identified significantly altered brain regions.
Main Results:
- Ketamine increased fALFF in the prefrontal cortex, caudate nucleus, and putamen.
- Regional homogeneity (ReHo) increased in the nucleus accumbens, caudate nucleus, and hippocampus.
- A decrease in ReHo was observed in the prefrontal cortex post-ketamine.
Conclusions:
- Single-dose ketamine administration alters regional brain activity intensity and synchronism.
- Findings provide evidence for ketamine-induced abnormal resting-state functional properties in primates.
- This study contributes to understanding ketamine's effects on the brain's resting state.
