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Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Asthma-I: Introduction01:29

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Cystic Fibrosis: Pathogenesis01:23

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Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
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COPD: Pathogenesis and Clinical Features01:20

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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
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Related Experiment Video

Updated: Feb 25, 2026

Sample Preparation and Analysis of RNASeq-based Gene Expression Data from Zebrafish
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Pathway discovery using transcriptomic profiles in adult-onset severe asthma.

Pieter-Paul Hekking1, Matt J Loza2, Stelios Pavlidis3

  • 1Respiratory Medicine, Academic Medical Centre, Amsterdam, The Netherlands.

The Journal of Allergy and Clinical Immunology
|July 31, 2017
PubMed
Summary

Adult-onset severe asthma involves specific inflammatory pathways, including eosinophils and mast cells. Identifying these pathways offers potential new targets for treating severe asthma in adults.

Keywords:
Adult-onset asthmaILC3eosinophilsgene set variation analysismast cellsmechanismsphenotypingsevere asthmatranscriptomics

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Area of Science:

  • Pulmonary Medicine
  • Immunology
  • Genetics

Background:

  • Adult-onset severe asthma presents as a complex, heterogeneous condition requiring targeted treatment strategies.
  • Understanding the molecular pathways underlying adult-onset severe asthma is crucial for developing effective therapies.

Purpose of the Study:

  • To identify distinct gene expression profiles associated with adult-onset severe asthma.
  • To compare these profiles with those of childhood-onset severe asthma.

Main Methods:

  • Cross-sectional observational study utilizing the U-BIOPRED cohort.
  • Gene expression analysis performed on induced sputum, nasal brushings, endobronchial brushings, and biopsies.
  • Gene set variation analysis applied to identify differentially enriched gene signatures.

Main Results:

  • Significant gene signatures were identified in nasal brushings, sputum, and endobronchial brushings when comparing adult-onset and childhood-onset severe asthma.
  • Enrichment of signatures related to eosinophilic airway inflammation, mast cells, and group 3 innate lymphoid cells was observed in adult-onset severe asthma.
  • Signatures associated with induced lung injury were less prevalent in adult-onset severe asthma.

Conclusions:

  • Adult-onset severe asthma is characterized by specific inflammatory pathways involving eosinophils, mast cells, and group 3 innate lymphoid cells.
  • These identified inflammatory pathways represent potential therapeutic targets for managing adult-onset severe asthma.