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Updated: Feb 25, 2026
08:10
Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
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Association between oxidative stress and atrial fibrillation
Ayman Samman Tahhan1, Pratik B Sandesara1, Salim S Hayek1
1Division of Cardiology, Emory University School of Medicine, Emory Clinical Cardiovascular Research Institute, Atlanta, Georgia.
Heart Rhythm
|August 1, 2017
Summary
Oxidative stress, indicated by glutathione redox potential, is linked to atrial fibrillation (AF) development and occurrence. Further research into therapies targeting oxidative stress is crucial for AF prevention and treatment.
Area of Science:
- Cardiology
- Biochemistry
- Oxidative Stress Research
Background:
- Oxidative stress (OS) is a suspected mechanism in atrial fibrillation (AF) development, but human data are scarce.
- Systemic OS can be assessed via circulating aminothiols like glutathione and cysteine.
Purpose of the Study:
- To investigate the association between the redox potentials of glutathione (EhGSH) and cysteine and prevalent and incident AF.
- To determine if OS markers independently predict AF after adjusting for known risk factors.
Main Methods:
- Plasma aminothiols were measured in 1439 patients undergoing coronary angiography.
- Multivariate logistic and Cox regression models analyzed the relationship between OS markers and AF, controlling for confounders.
Main Results:
- Each 10% increase in EhGSH correlated with higher odds of prevalent AF (OR 1.3) and incident AF (HR 1.4).
- Higher EhGSH levels were more predictive of chronic AF than paroxysmal AF.
- Significant associations were found even after adjusting for traditional risk factors and inflammatory markers.
Conclusions:
- Elevated OS, as indicated by glutathione redox potential, is significantly associated with both prevalent and incident AF.
- Investigating therapies that modulate OS is essential for developing new strategies to treat and prevent AF.
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