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Double Trouble: A Case Series on Concomitant Genetic Aberrations in NSCLC

Nele Van Der Steen1, Yves Mentens2, Marc Ramael3

  • 1Center for Oncological Research, University of Antwerp, Antwerp, Belgium; Department of Pathology, Antwerp University Hospital, Antwerp, Belgium; Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands.

Clinical Lung Cancer
|August 1, 2017
PubMed

Insights

Identifying targeted therapy for non-small cell lung cancer with multiple driver mutations is challenging. This case series reviews responses to targeted therapies in patients with double oncogenic driver mutations, including EGFR and ALK.

Area of Science:

  • Oncology
  • Genetics
  • Pharmacology

Background:

  • Non-small cell lung cancer (NSCLC) treatment increasingly involves targeted therapies for specific oncogenic drivers.
  • Advancements in genetic testing reveal more NSCLC cases with multiple driver mutations, posing treatment selection challenges.

Observation:

  • This case series examines patient responses to targeted therapies for NSCLC with intrinsic double oncogenic driver mutations.
  • Focus areas include epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), cMET, and Kirsten rat sarcoma viral oncogene (KRAS).
  • An unpublished case of a patient with concurrent EGFR L858R and cMET exon 14 skipping mutations is presented.

Findings:

  • The study analyzes the efficacy of targeted therapies in NSCLC patients harboring dual oncogenic driver mutations.
  • Specific attention is given to the effectiveness of treatments targeting EGFR, ALK, cMET, and KRAS pathways.

Implications:

  • Findings may aid clinicians in selecting appropriate targeted therapies for NSCLC patients with complex mutational profiles.
  • Understanding treatment responses in double-mutation NSCLC can guide future therapeutic strategies and drug development.
Keywords:
ALKEGFRKRASNon–small cell lung cancercMET

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