Related Experiment Video
Updated: Jan 9, 2026
Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing
Published on: December 13, 2024
Evaluation of chemical modified hydrogel formulation for topical suitability
1Department of Pharmaceutical Technology, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Austria; Massachusetts Institute of Technology, Koch Institute for Integrative Cancer Research at MIT, Langer Lab, 77 Massachussets Ave, Cambridge, MA, 02139, USA.
Background:
Skin delivery and transdermal delivery are key ambitions of the pharmaceutical and cosmetically researchers.
Aim:
The study aimed to chemically modify well-known polymeric gelling agents in order to boost their topical suitability by fostering their dermal adhesiveness.
Methods:
Conventional chitosan was modified via amide bound formation with sulfhydryl compound thioglycolic acid. Subsequently, preactivated chitosan conjugate was established by preactivation of chitosan-thioglycolic acid with mercaptonicotinamide being covalently attached via disulfide bond linkage. All conjugates were examined due to their dermal adhesiveness and controlled drug release properties.
Results:
Preactivated chitosan conjugates Exhibit 7.46-fold dermal adhesiveness on skin due to tensile adhesion strength. Furthermore a 1.9-fold controlled release of Rhodamine123 as model drug was determined in comparison to unmodified chitosan.
Conclusion:
Taken together, preactivated chitosan gels show a promising platform for topical application.
