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Updated: Feb 25, 2026

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Will we ever have better glucocorticoids?

Frank Buttgereit1, Johannes W J Bijlsma2, Cindy Strehl1

  • 1Department of Rheumatology and Clinical Immunology, Charité University Hospital (CCM), Berlin, Germany.

Clinical Immunology (Orlando, Fla.)
|August 1, 2017
PubMed
Summary
This summary is machine-generated.

Glucocorticoids effectively treat inflammatory diseases but can cause harm. Research focuses on optimizing dosing and developing new therapies like liposomal glucocorticoids and dissociated agonists to minimize side effects.

Keywords:
Benefit-risk ratioGlucocorticoid therapyLiposomal glucocorticoidsSelective glucocorticoid receptor agonists

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Area of Science:

  • Rheumatology
  • Pharmacology
  • Drug Development

Background:

  • Glucocorticoids are essential anti-inflammatory and immunosuppressive drugs for rheumatic diseases.
  • Prolonged use or high doses of glucocorticoids can lead to significant adverse effects.
  • Optimizing glucocorticoid therapy is crucial for balancing efficacy and safety.

Purpose of the Study:

  • To review current strategies for minimizing glucocorticoid adverse effects.
  • To highlight innovative approaches in glucocorticoid therapy.
  • To discuss the therapeutic balance between anti-inflammatory efficacy and harm.

Main Methods:

  • Review of recent publications on glucocorticoid therapy.
  • Focus on liposomal glucocorticoids.
  • Focus on dissociated agonists of the glucocorticoid receptor.

Main Results:

  • Optimal dosing, monitoring, and management are key to reducing glucocorticoid harm.
  • Liposomal formulations may improve drug delivery and reduce systemic exposure.
  • Dissociated agonists aim to separate anti-inflammatory effects from adverse effects.

Conclusions:

  • Minimizing adverse effects of glucocorticoids is an active area of research.
  • Liposomal glucocorticoids and dissociated agonists show promise for safer and more effective treatment.
  • Further development is needed to optimize these novel approaches for clinical use.