Related Experiment Video

Updated: Feb 25, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.5K

Association of Blood Pressure Control Level With Left Ventricular Morphology and Function and With Subclinical

Koki Nakanishi1, Zhezhen Jin2, Shunichi Homma1

  • 1Department of Medicine, Columbia University, New York, NY.

Journal of the American Heart Association
|August 1, 2017
PubMed

Insights

Intensive systolic blood pressure control significantly benefits cardiac health in elderly hypertensive patients, reducing left ventricular hypertrophy. However, it showed no significant impact on subclinical cerebrovascular disease.

Area of Science:

  • Cardiology
  • Neurology
  • Hypertension Research

Background:

  • Hypertension can lead to target organ damage in the heart and brain.
  • Left ventricular (LV) hypertrophy and subclinical cerebrovascular disease are early indicators of this damage.
  • Elderly hypertensive patients are particularly vulnerable to these complications.

Purpose of the Study:

  • To evaluate the impact of intensive systolic blood pressure (SBP) control on LV morphology and function.
  • To assess the effect of intensive SBP control on subclinical cerebrovascular disease in elderly hypertensive patients.
  • To compare the benefits of intensive versus less intensive SBP control on cardiac and cerebral outcomes.

Main Methods:

  • The study involved 420 hypertensive patients without prior heart failure or stroke from the CABL study.
  • Patients underwent 2D echocardiography and brain MRI.
  • Three SBP control groups were defined: intensive (<120 mmHg), less intensive (120-139 mmHg), and uncontrolled (≥140 mmHg).

Main Results:

  • LV hypertrophy and diastolic dysfunction were significantly lower in the intensive SBP control group compared to less intensive and uncontrolled groups.
  • Less intensive SBP control was associated with a higher risk of LV hypertrophy (aOR, 3.26; P=0.013).
  • Intensive SBP control did not significantly reduce the risk of silent brain infarcts or white matter hyperintensity volume.

Conclusions:

  • Intensive systolic blood pressure control demonstrates a more pronounced beneficial effect on cardiac subclinical disease than on cerebral subclinical disease.
  • These findings suggest a differential impact of intensive BP management on target organ protection.
  • Further research may explore optimal SBP targets for comprehensive cardiovascular and cerebrovascular risk reduction.
Abstract

Keywords:
blood pressurehypertensionleft ventricular diastolic dysfunctionleft ventricular hypertrophysilent brain infarction

More Related Videos

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

5.1K
A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

16.9K

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
667
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.2K
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
4.6K
Factors affecting Blood pressure01:28

Factors affecting Blood pressure

Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
7.4K
Regulation of Stroke Volume01:27

Regulation of Stroke Volume

The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
5.4K
Pre-Procedural Guidelines for Assessing Blood Pressure01:10

Pre-Procedural Guidelines for Assessing Blood Pressure

Accurate blood pressure assessment is crucial for diagnosing and managing various health conditions. To ensure the reliability of these measurements, healthcare professionals must adhere to standardized pre-procedural guidelines. These guidelines enhance patient safety and improve the overall quality of healthcare. The following steps are essential for obtaining accurate and consistent blood pressure readings, from using the appropriate tools to ensuring effective communication with the...
911