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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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Updated: Feb 25, 2026

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
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Genetic Breast Cancer Susceptibility Variants and Prognosis in the Prospectively Randomized SUCCESS A Study.

A Hein1, B Rack2, L Li3,4

  • 1Department of Gynecology and Obstetrics, Erlangen University Hospital, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.

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Summary

This study found that a specific genetic marker, rs3817198 in LSP1, impacts breast cancer (BC) survival. This single nucleotide polymorphism (SNP) offers prognostic value, especially for triple-negative BC patients.

Keywords:
LSP1SNPTNBCbreast cancerprognosis

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Area of Science:

  • Oncology
  • Genetics
  • Cancer Prognostics

Background:

  • Over 70 single nucleotide polymorphisms (SNPs) are linked to breast cancer (BC) risk.
  • Limited understanding exists regarding genetic factors influencing BC prognosis.

Purpose of the Study:

  • To investigate the prognostic impact of nine known BC risk SNPs.
  • To analyze SNP associations with overall survival (OS) and progression-free survival (PFS) in BC patients.

Main Methods:

  • Genotyping of 1687 BC patients from the SUCCESS A trial for nine BC risk SNPs.
  • Cox proportional hazards models used to assess SNP associations with OS and PFS.
  • Subgroup analyses conducted for molecular subtypes.

Main Results:

  • The SNP rs3817198 (LSP1) was the sole significant predictor of OS and PFS.
  • Triple-negative BC patients with two rs3817198 minor alleles showed improved OS and PFS.
  • Luminal A tumors showed improved PFS with rs3817198 minor alleles, while luminal B tumors showed poorer PFS.

Conclusions:

  • The rs3817198 variant in LSP1 demonstrates significant prognostic value in breast cancer.
  • This SNP's effect is particularly pronounced in triple-negative BC, suggesting a potential role in immunomodulation.
  • Findings highlight the importance of genetic markers in predicting breast cancer patient outcomes.