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Circulating Th1, Th2, and Th17 Levels in Hypertensive Patients

Qingwei Ji1, Guojie Cheng2, Ning Ma2

  • 1Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, and Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing 100029, China.

Disease Markers
|August 1, 2017
PubMed

Insights

Altered levels of T helper 1 (Th1), T helper 2 (Th2), and T helper 17 (Th17) cells are linked to hypertension. Specifically, increased Th1 and Th17 and decreased Th2 activity correlate with nondipper hypertension and carotid plaque.

Area of Science:

  • Immunology
  • Cardiovascular Medicine
  • Hypertension Research

Background:

  • T helper 1 (Th1), T helper 2 (Th2), and T helper 17 (Th17) cells are implicated in hypertension pathogenesis and target organ damage.
  • The association between circulating Th1, Th2, and Th17 levels and nondipper hypertension with carotid atherosclerotic plaque remains unexamined.

Purpose of the Study:

  • To investigate the relationship between circulating Th1, Th2, and Th17 cell levels and the presence of nondipper hypertension and carotid atherosclerotic plaque.

Main Methods:

  • Flow cytometry was used to quantify Th1, Th2, and Th17 cell frequencies.
  • Enzyme-linked immunosorbent assay (ELISA) measured associated cytokine levels (IFN-γ, IL-17, and IL-4).
  • The study included 45 hypertensive patients and 15 normotensive controls.

Main Results:

  • Hypertensive patients, particularly those with nondipper status and carotid plaque, exhibited significantly higher Th1 and Th17 frequencies and elevated IFN-γ and IL-17 levels.
  • Conversely, these patients showed significantly lower Th2 frequencies and reduced IL-4 levels compared to controls.
  • These findings suggest distinct T helper cell profiles associated with specific hypertension subtypes and complications.

Conclusions:

  • Alterations in Th1, Th2, and Th17 cell activity are associated with the development of nondipper hypertension.
  • Changes in Th1, Th2, and Th17 cell activity are linked to the presence of carotid atherosclerotic plaque in hypertensive individuals.
  • These T helper cell imbalances may play a role in hypertension progression and associated vascular complications.
Abstract

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