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Related Experiment Video

Updated: Feb 25, 2026

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Bone scintigraphy in patients with pain.

Seung Hyeon Shin1, Seong Jang Kim2,3

  • 1Department of Nuclear Medicine, Pusan National University Hospital, Busan, Korea.

The Korean Journal of Pain
|August 1, 2017
PubMed
Summary

Nuclear medicine imaging, including bone scintigraphy and SPECT/CT, offers valuable insights for diagnosing low back pain and extremity conditions like complex regional pain syndrome (CRPS). These techniques provide additional diagnostic information beyond conventional imaging.

Keywords:
Complex regional pain syndromeDiagnostic imagingExtremity painLow back painNuclear medicineRadionuclide imagingSPECT CT

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Area of Science:

  • Nuclear Medicine
  • Radiology
  • Pain Medicine

Background:

  • Low back pain affects 49-70% of the population, often evaluated with CT or MRI, which can show incidental findings in asymptomatic individuals.
  • Complex Regional Pain Syndrome (CRPS) is a painful extremity disorder with sensory, autonomic, vasomotor, and trophic disturbances.

Purpose of the Study:

  • To highlight the additional diagnostic value of nuclear medicine imaging in evaluating low back pain and extremity pain.
  • To emphasize the utility of three-phase bone scintigraphy in diagnosing CRPS and SPECT/CT in assessing extremity pain.

Main Methods:

  • Review of the application of nuclear medicine imaging techniques in pain medicine.
  • Comparison of bone scintigraphy and SPECT/CT with conventional imaging modalities like CT and MRI.

Main Results:

  • Bone scintigraphy provides additional value in patients with low back pain where CT/MRI findings may be non-specific.
  • Three-phase bone scintigraphy is considered superior for CRPS diagnosis and has high specificity for ruling out the condition.
  • SPECT/CT plays a significant role in assessing extremity pain, offering benefits beyond ultrasound, CT, and MRI.

Conclusions:

  • Nuclear medicine imaging, particularly bone scintigraphy and SPECT/CT, offers unique diagnostic advantages in pain management.
  • These advanced imaging techniques are crucial for accurate diagnosis and management of complex pain conditions affecting the back and extremities.