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Nuria Rodríguez-Vázquez1, Rebeca García-Fandiño1, Manuel Amorín1

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Area of Science:

  • Supramolecular Chemistry
  • Peptide Self-Assembly
  • Organic Synthesis

Background:

  • Self-assembling peptides are crucial for creating novel nanomaterials.
  • Cyclic peptides offer unique structural stability and defined conformations.
  • Controlling cavity size and properties is key for molecular recognition applications.

Purpose of the Study:

  • To design and synthesize novel beta-sheet-based cyclic peptides.
  • To create self-assembling peptide systems with tunable internal cavities.
  • To investigate the influence of guest molecules on aggregate formation.

Main Methods:

  • Design of cyclic peptide scaffolds incorporating gamma-amino acids.
  • Synthesis of peptide monomers and subsequent cyclization.
  • Characterization of self-assembled dimeric ensembles.
  • Guest entrapment studies to determine binding properties.

Main Results:

  • Successfully synthesized beta-sheet-based cyclic peptides.
  • Demonstrated tunable cavity formation through gamma-amino acid modification.
  • Showcased the ability of peptide dimers to entrap various guests.
  • Established a correlation between guest properties and aggregate geometry.

Conclusions:

  • The developed cyclic peptides form self-assembling dimeric ensembles with tunable cavities.
  • The internal cavity properties can be modulated by incorporating different functional groups via a gamma-amino acid.
  • The nature of the entrapped guest molecule dictates the final aggregate structure, offering a pathway for controlled self-assembly.