Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

4.0K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
4.0K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

10.0K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
10.0K
Inflammation01:38

Inflammation

62.8K
Overview
62.8K
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

1.4K
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
1.4K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

2.1K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.1K
Introduction to Hemostasis01:05

Introduction to Hemostasis

15.2K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
15.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Self-Assembly of Modular Bis-MPA Dendrons into Colloidal Particles with Tunable Morphology and Selective Cytotoxicity.

Nanomaterials (Basel, Switzerland)·2026
Same author

The Role of Reticulocyte-Derived Parameters in the Detection of Iron-Restricted Erythropoiesis in the Elderly.

Diagnostics (Basel, Switzerland)·2026
Same author

Neuroprotection and activation of anti-inflammatory and plasticity mechanisms by PLC-β inhibition after cholinergic hyperstimulation in hippocampal slices and microglial cells.

IBRO neuroscience reports·2026
Same author

Reticulocyte hemoglobin in the evaluation of erythropoietic activity and iron availability.

Blood transfusion = Trasfusione del sangue·2024
Same author

Deferasirox's Anti-Chemoresistance and Anti-Metastatic Effect on Non-Small Cell Lung Carcinoma.

Biomedicines·2024
Same author

Complete Blood Counts and Research Parameters in the Detection of Myelodysplastic Syndromes.

Diagnostics (Basel, Switzerland)·2024
Same journal

Mycobacterial Nucleic Acids Modulate Host Innate Immune Responses.

Journal of infectious disease and therapy·2024
Same journal

To What Extent do Social Determinants of Health Modulate Presentation, ITU Admission and Outcomes among Patients with SARS-COV-2 Infection? An Exploration of Household Overcrowding, Air Pollution, Housing Quality, Ethnicity, Comorbidities and Frailty.

Journal of infectious disease and therapy·2023
Same journal

Insulin Resistance is Associated with Higher Plasma Viral Load Among HIV-Positive Adults Receiving Longer-Term (1 Year) Combination Antiretroviral Therapy (ART).

Journal of infectious disease and therapy·2022
Same journal

Combating Malaria: Where do We Stand?

Journal of infectious disease and therapy·2016
Same journal

Disturbances of Tryptophan Metabolism and Risk of Depression in HCV Patients Treated with IFN-Alpha.

Journal of infectious disease and therapy·2014
See all related articles

Related Experiment Video

Updated: Feb 25, 2026

An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers
05:43

An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers

Published on: November 8, 2024

861

Emerging Roles for Platelets in Inflammation and Disease.

Yancy Ferrer-Acosta1, Marieli González2, Mónica Fernández3

  • 1University of Puerto Rico, Rio Piedras Campus, San Juan, Puerto Rico, USA.

Journal of Infectious Disease and Therapy
|August 1, 2017
PubMed
Summary
This summary is machine-generated.

Platelets interact with immune cells to regulate hemostasis and inflammation. Novel receptors like CLEC-2 and TLT-1 reveal new platelet roles in host defense and managing inflammation.

More Related Videos

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice
11:18

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice

Published on: April 2, 2013

16.2K
Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.7K

Related Experiment Videos

Last Updated: Feb 25, 2026

An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers
05:43

An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers

Published on: November 8, 2024

861
Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice
11:18

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice

Published on: April 2, 2013

16.2K
Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.7K

Area of Science:

  • Immunology
  • Hematology
  • Cell Biology

Background:

  • Platelets are crucial for hemostasis and inflammation.
  • They interact with immune cells like lymphocytes, monocytes, and neutrophils.
  • Platelets play emerging roles in host defense.

Purpose of the Study:

  • To review the evolving understanding of platelet functions.
  • To highlight novel platelet mechanisms in hemostasis during inflammation.
  • To discuss the roles of CLEC-2 and TLT-1 receptors.

Main Methods:

  • Literature review of platelet research.
  • Analysis of molecular mechanisms of platelet-immune cell interactions.
  • Focus on C-type lectin receptor 2 (CLEC-2) and TREM-like transcript-1 (TLT-1).

Main Results:

  • Platelets recruit and modulate immune cell functions.
  • Platelet Toll-like receptors direct neutrophil responses against pathogens.
  • CLEC-2 and TLT-1 influence hemostatic and inflammatory platelet activities.

Conclusions:

  • Platelets are key mediators of both hemostasis and inflammation.
  • Platelet receptors like CLEC-2 and TLT-1 offer new therapeutic targets.
  • Understanding platelet roles in inflammation is critical for host defense.