Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

17.5K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
17.5K
Inflammation01:38

Inflammation

62.8K
Overview
62.8K
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

602
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
602
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

762
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
762
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

17.4K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
17.4K
T Cell Types and Functions01:24

T Cell Types and Functions

2.8K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resolution Failure in Periodontal Diseases: Dysregulated Pro-resolving Mechanisms in Chronic Inflammation and Tissue Breakdown.

Current topics in microbiology and immunology·2026
Same author

Periodontitis as a Model for Inflammatory Uncoupling of Bone Remodeling.

Journal of periodontal research·2026
Same author

Protection Against Periodontitis by Improving Mitochondrial Function in Diabetes.

Diabetes·2026
Same author

Downregulation of osteoclast differentiation and activation by the soluble epoxide hydrolase inhibition.

The Journal of pharmacology and experimental therapeutics·2026
Same author

Editorial: Diabetes and oral health.

Frontiers in clinical diabetes and healthcare·2026
Same author

Microbial dysbiosis and immune dysregulation in periodontitis and peri-implantitis.

Frontiers in cellular and infection microbiology·2026

Related Experiment Video

Updated: Feb 25, 2026

Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses
06:43

Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses

Published on: March 29, 2017

10.5K

Host modulation: controlling the inflammation to control the infection.

P Mark Bartold, Thomas E Van Dyke

    Periodontology 2000
    |August 1, 2017
    PubMed
    Summary

    Periodontal disease is driven by the host

    Area of Science:

    • Periodontology
    • Immunology
    • Microbiology

    Background:

    • Periodontal disease historically attributed to bacterial origin.
    • Bacteria are necessary but not sufficient for disease manifestation.
    • Host inflammatory response is key to tissue damage and disease progression.

    Purpose of the Study:

    • To explore the role of the subgingival microenvironment in periodontitis.
    • To examine evidence for inflammation's central role in pathogenesis.
    • To propose a 'treat to target' model for periodontal patient monitoring.

    Main Methods:

    • Review of emerging evidence on periodontitis pathogenesis.
    • Analysis of the host inflammatory response to subgingival bacteria.
    • Conceptual model development for patient management.

    More Related Videos

    Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
    12:50

    Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

    Published on: September 15, 2017

    7.0K
    Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
    11:12

    Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

    Published on: September 13, 2024

    983

    Related Experiment Videos

    Last Updated: Feb 25, 2026

    Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses
    06:43

    Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses

    Published on: March 29, 2017

    10.5K
    Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
    12:50

    Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

    Published on: September 15, 2017

    7.0K
    Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
    11:12

    Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

    Published on: September 13, 2024

    983

    Main Results:

    • Inflammation, not specific microbiota, plays a central role in periodontitis.
    • The subgingival microenvironment is modified by inflammation, altering microbiota.
    • Controlling inflammation is proposed as a method to control infection.

    Conclusions:

    • The host inflammatory response is crucial in periodontitis pathogenesis.
    • A paradigm shift supports inflammation-centric disease models.
    • A 'treat to target' approach offers a new model for periodontal care.