Eccrine Chromhidrosis in an Adolescent with Sickle Cell Disease.

Area of Science:

• Dermatology
• Hematology
• Pediatrics

Background:

• Eccrine chromhidrosis is a rare condition characterized by colored sweat.
• It can be associated with conditions causing hyperbilirubinemia, such as liver disease or hemolytic anemia.

Observation:

• An adolescent patient with sickle cell disease presented with eccrine chromhidrosis.
• The discoloration was observed on the palmar and plantar surfaces.
• The patient exhibited markedly elevated conjugated bilirubin levels without fever.

Findings:

• This case represents the youngest reported individual with eccrine chromhidrosis.
• It is the first documented instance of eccrine chromhidrosis in a patient with sickle cell disease.
• The findings suggest a link between severe hyperbilirubinemia in sickle cell disease and eccrine chromhidrosis.

Implications:

• Highlights a novel cutaneous manifestation of hyperbilirubinemia in sickle cell disease.
• Suggests the need for dermatological evaluation in sickle cell patients with unexplained skin discoloration.
• Expands the understanding of eccrine chromhidrosis pathophysiology and its association with hematologic disorders.