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Updated: Feb 25, 2026

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
Published on: June 7, 2016
Brain Angiotensin II Involvement in Chronic Mental Disorders
Osvaldo Martin Basmadjian1, Victoria Belen Occhieppo1, Natalia Andrea Marchese1
1Instituto de Farmacologia Experimental Cordoba (IFEC-CONICET) Departamento de Farmacologia, Facultad de Ciencias QuImicas Universidad Nacional de Cordoba, Cordoba, Argentina.
Brain angiotensin II (Ang II) influences neurotransmission implicated in CNS disorders. Targeting brain Ang II offers a potential therapeutic strategy for conditions like Alzheimer's, Parkinson's, and schizophrenia.
Area of Science:
- Neuroscience
- Pharmacology
- Molecular Biology
Background:
- Central nervous system (CNS) disorders stem from neurotransmitter imbalances.
- Brain angiotensin II (Ang II) and its AT1 receptors modulate key neurotransmitter systems.
- Dysregulation of the brain renin-angiotensin system (RAS) is linked to CNS pathologies.
Purpose of the Study:
- To investigate the role of brain Ang II in CNS disorders.
- To explore the therapeutic potential of targeting brain Ang II.
Main Methods:
- Review of existing literature on brain RAS and CNS disorders.
- Analysis of preclinical and epidemiological data.
- Exploration of Ang II's interaction with dopaminergic, glutamatergic, and GABAergic pathways.
Main Results:
- Altered brain RAS components are associated with depression, Parkinson's, Alzheimer's, and schizophrenia.
- Ang II modulates neurotransmission pathways implicated in these disorders.
- Evidence suggests a link between RAS and susceptibility to CNS diseases.
Conclusions:
- Brain Ang II is a potential therapeutic target for CNS disorders.
- Targeting brain Ang II may offer novel treatment strategies.
- Further research is warranted to validate Ang II as a therapeutic target.
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