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Related Experiment Video

Updated: Feb 25, 2026

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis
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Complement Gene Expression Correlates with Superior Frontal Cortical Thickness in Humans.

Dana M Allswede1, Amanda B Zheutlin1, Yoonho Chung1

  • 1Department of Psychology, Yale University.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|August 1, 2017
PubMed
Summary

Complement gene expression, specifically C5 and SERPING1, is linked to superior frontal cortical thickness in humans. This finding supports the role of the complement system in schizophrenia pathogenesis and cortical thinning.

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Area of Science:

  • Neuroscience
  • Immunology
  • Genetics

Background:

  • Innate immune system complement proteins may increase schizophrenia risk by affecting synaptic pruning.
  • Complement pathway alterations are implicated in cortical thinning observed in schizophrenia.

Purpose of the Study:

  • To investigate the relationship between complement gene expression and cortical thickness in humans.
  • To assess the role of the complement system in the etiology of schizophrenia.

Main Methods:

  • Analysis of peripheral mRNA expression of complement genes (C5, SERPING1) in adult Swedish twins.
  • Vertex-wise mapping of gene expression and cortical thickness associations.
  • Examination of gene expression in human superior frontal cortex.

Main Results:

  • Peripheral mRNA levels of C5 and SERPING1 uniquely contributed to superior frontal cortical thickness variance.
  • A strong association between SERPING1 expression and superior frontal cortical thickness was observed.
  • These complement genes are expressed in the human superior frontal cortex, with heritable factors influencing SERPING1 expression.

Conclusions:

  • Provides initial evidence linking the complement system to cortical thinning in humans.
  • Suggests a potential mechanism involving the complement system in schizophrenia pathogenesis.
  • Findings are consistent across schizophrenia cases and controls.