Correction: Dependence of gold nanoparticle radiosensitization on cell geometry
Wonmo Sung1, Sung-Joon Ye, Aimee L McNamara
1Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA. jschuemann@mgh.harvard.edu.
Nanoscale
|August 1, 2017
Summary
This correction clarifies how gold nanoparticle radiosensitization depends on cell geometry. It refines understanding of nanoparticle interactions with cells for cancer therapy.
Area of Science:
- Nanomedicine
- Radiotherapy
- Cellular Biophysics
Background:
- Gold nanoparticles (AuNPs) are investigated for enhancing radiotherapy efficacy.
- Cell geometry and nanoparticle distribution significantly influence radiation dose enhancement.
- Previous studies suggested a dependence of AuNP radiosensitization on cell geometry.
Purpose of the Study:
- To correct and clarify the findings presented in the original article regarding AuNP radiosensitization.
- To provide accurate data on the relationship between cell geometry and radiosensitizing effects of AuNPs.
Main Methods:
- Re-analysis of experimental data and simulations.
- Focus on the impact of cell shape and size on absorbed dose enhancement.
Main Results:
- The radiosensitization effect of gold nanoparticles is indeed dependent on cell geometry.
- Specific geometric factors were identified as critical for optimizing radiosensitization.
Conclusions:
- Accurate modeling of cell geometry is crucial for predicting gold nanoparticle radiosensitization.
- This correction refines the understanding of physical mechanisms underlying nanoparticle-enhanced radiotherapy.
