Multimodality assessment of left ventricular dysfunction in Takayasu arteritis and familial hypercholesterolaemia

Area of Science:

• Cardiology
• Rheumatology
• Genetics

Background:

• Takayasu arteritis (TA) is a large vessel vasculitis.
• Left ventricular (LV) systolic dysfunction is a known complication of TA.
• The development of heart failure in TA patients requires further investigation.

Observation:

• A patient with active Takayasu arteritis (TA) and familial hypercholesterolemia presented with severe LV dysfunction.
• Multimodality assessments were used to evaluate LV systolic function.
• This presentation is novel and not previously reported.

Findings:

• Active TA combined with familial hypercholesterolemia can lead to severe LV systolic dysfunction.
• The findings suggest a potential link between these conditions and cardiac impairment.
• Detailed assessment revealed significant abnormalities in LV systolic function.

Implications:

• This case highlights the importance of cardiac evaluation in TA patients, especially those with additional risk factors like familial hypercholesterolemia.
• Early recognition and management of LV dysfunction in TA are crucial for preventing heart failure progression.
• Further research is warranted to understand the mechanisms underlying LV dysfunction in TA and its association with genetic lipid disorders.