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Age-related decrease in endothelium-dependent dilator response to histamine in rat mesenteric artery.

H Moritoki, E Hosoki, Y Ishida

    European Journal of Pharmacology
    |July 15, 1986
    PubMed
    Summary
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    Aging diminishes vasodilator responses in rat mesenteric arteries, particularly to histamine. This age-related decline is linked to reduced endothelial mediator release, impacting blood flow regulation.

    Area of Science:

    • Vascular Physiology
    • Aging Research
    • Pharmacology

    Background:

    • Vascular responses to vasodilators change with age.
    • Histamine and related compounds are key mediators of vascular tone.
    • The role of aging on endothelial function in mesenteric arteries is not fully understood.

    Purpose of the Study:

    • To investigate the impact of aging on vasodilator responses in rat mesenteric arteries.
    • To determine the specific mechanisms underlying age-related changes in histamine-induced vasodilation.
    • To assess the involvement of endothelial factors in these age-dependent alterations.

    Main Methods:

    • Vascular ring segments from rats of different ages (2-99 weeks) were used.
    • Dose-response curves for histamine, 2-pyridylethylamine, 4-methylhistamine, and papaverine were generated.

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  • The effects of H1 and H2 antagonists, endothelial removal, and specific inhibitors (hydroquinone, methylene blue) were examined.

    • Main Results:

    • Histamine-induced vasodilation peaked in young rats (2-8 weeks) and significantly decreased with age.
    • Responses to 2-pyridylethylamine and 4-methylhistamine also showed age-dependent declines.
    • Endothelial removal abolished histamine's effect, while papaverine's effect remained unchanged.
    • Inhibitors of nitric oxide and other mediators reversed histamine-induced vasodilation.

    Conclusions:

    • Aging significantly impairs vasodilator responses in rat mesenteric arteries, especially to histamine.
    • The age-related decrease is primarily attributed to diminished endothelial mediator release.
    • These findings highlight age-related endothelial dysfunction impacting vascular reactivity.