Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

5.7K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
5.7K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.2K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.2K
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

3.5K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.5K
Stem Cell Culture01:17

Stem Cell Culture

6.3K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
6.3K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.2K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.2K
Embryonic Stem Cells00:57

Embryonic Stem Cells

5.5K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
5.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytarabine-based induction and oral maintenance therapy for a single system with single-site Langerhans cell histiocytosis.

International journal of hematology·2026
Same author

Utility of Integrating Genome-Wide Postmortem Testing into Clinical Autopsy Practice in Pediatrics: A Retrospective, Single-Center Study.

Fetal and pediatric pathology·2026
Same author

A case of orbital solitary fibrous tumor with fast-growing budding morphology.

Orbit (Amsterdam, Netherlands)·2026
Same author

Continuous versus Intermittent Midazolam Sedation in Balloon-Assisted Enteroscopy: A Multicenter Randomized Trial.

Digestion·2026
Same author

Clinical Significance of Molecular Genetic Analysis in Diffuse Intrinsic Pontine Glioma: Two Case Reports.

Pediatric blood & cancer·2025
Same author

Repeat-associated non-AUG translation as a common mechanism for the polyGln ataxias.

Cell reports·2025

Related Experiment Video

Updated: Feb 25, 2026

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System
08:00

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

Published on: May 14, 2015

32.3K

A pathologist's perspective on induced pluripotent stem cells.

Noriko Watanabe1, Katherine E Santostefano1,2, Anthony T Yachnis1

  • 1Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA.

Laboratory Investigation; a Journal of Technical Methods and Pathology
|August 1, 2017
PubMed
Summary

Induced pluripotent stem cell (iPSC) technology offers a powerful tool for studying disease pathobiology. This review explores iPSC applications for pathologists, focusing on recapitulating disease morphology using organoid differentiation.

More Related Videos

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

1.5K
Author Spotlight: Advancements in iPSCs and Genetic Disease Research
06:24

Author Spotlight: Advancements in iPSCs and Genetic Disease Research

Published on: October 20, 2023

1.9K

Related Experiment Videos

Last Updated: Feb 25, 2026

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System
08:00

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

Published on: May 14, 2015

32.3K
Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

1.5K
Author Spotlight: Advancements in iPSCs and Genetic Disease Research
06:24

Author Spotlight: Advancements in iPSCs and Genetic Disease Research

Published on: October 20, 2023

1.9K

Area of Science:

  • Stem Cell Biology
  • Pathology
  • Regenerative Medicine

Background:

  • Induced pluripotent stem cell (iPSC) technology, developed in 2006, reprograms somatic cells into pluripotent stem cells.
  • iPSCs possess the potential to differentiate into all cell types, making them valuable for disease research.
  • The application of iPSCs as a diagnostic or research tool for practicing pathologists is an emerging area.

Purpose of the Study:

  • To review the progress of iPSC technology in disease pathobiology studies.
  • To evaluate the future potential and challenges of iPSCs from a pathologist's viewpoint.
  • To highlight the use of three-dimensional stem cell cultures, like organoids, for modeling disease morphology.

Main Methods:

  • Review of current literature on induced pluripotent stem cell research.
  • Focus on studies utilizing iPSCs for disease pathobiology and morphological studies.
  • Emphasis on three-dimensional culture techniques, including organoid differentiation.

Main Results:

  • iPSCs are increasingly used to model various human diseases in vitro.
  • Organoid differentiation allows for the recapitulation of complex tissue structures and disease-related morphological changes.
  • Significant progress has been made in understanding disease mechanisms through iPSC-based models.

Conclusions:

  • iPSC technology holds considerable promise as a future research and diagnostic tool in pathology.
  • Further development is needed to overcome challenges related to standardization, scalability, and clinical translation.
  • Organoid models derived from iPSCs are crucial for studying disease-specific cellular and tissue-level alterations.