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Assessment of myocardial repolarisation parameters in patients with familial Mediterranean fever

Kayihan Karaman1, Metin Karayakali1, Ertuğrul Erken1

  • 1Department of Cardiology, Gaziosmanpasa University School of Medicine, Tokat, Turkey.

Cardiovascular Journal of Africa
|August 1, 2017
PubMed
Abstract

Insights

Familial Mediterranean Fever (FMF) patients show prolonged T-wave peak-to-end (Tp-Te) intervals and corrected Tp-Te (cTp-Te) ratios, indicating potential cardiovascular risks. These repolarisation alterations may help anticipate cardiac events in FMF.

Area of Science:

  • Cardiology
  • Genetics
  • Rheumatology

Background:

  • Familial Mediterranean Fever (FMF) is a chronic auto-inflammatory disorder causing recurrent fever and polyserositis.
  • Cardiovascular events are a leading cause of mortality in auto-inflammatory diseases.
  • Myocardial repolarisation parameters like T-wave peak-to-end (Tp-Te) may be affected in FMF.

Purpose of the Study:

  • To investigate myocardial repolarisation alterations in FMF patients.
  • To assess the potential of these alterations in predicting cardiovascular risks.

Main Methods:

  • Compared 66 FMF patients with 58 healthy controls.
  • Measured Tp-Te and corrected Tp-Te (cTp-Te) intervals and Tp-Te/QT ratios from 12-lead ECGs.

Main Results:

  • QT, QTc, and their dispersions were similar between groups.
  • FMF patients exhibited significantly prolonged Tp-Te and cTp-Te intervals and Tp-Te/QT and cTp-Te/QT ratios.
  • Elevated erythrocyte sedimentation rate independently predicted prolonged cTp-Te intervals.

Conclusions:

  • FMF patients demonstrate significantly increased Tp-Te and cTp-Te intervals and cTp-Te/QT ratios compared to controls.
  • These findings suggest potential utility in assessing cardiovascular risk in FMF.

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