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Updated: Feb 25, 2026

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
Published on: November 11, 2008
Facile Synthesis of In-Chain, Multicomponent, Functionalized Polymers via Living Anionic Copolymerization through the
Heyu Shen1, Hongwei Ma1, Pibo Liu1
1State Key Laboratory of Fine Chemicals, Liaoning Key Laboratory of Polymer Science and Engineering, Department of Polymer Science and Engineering, School of Chemical Engineering, Dalian University of Technology, Dalian, 116024, China.
Abstract:
By combining living anionic polymerization and the highly efficient Ugi four-component reaction (Ugi-4CR), in-chain, multicomponent, functionalized polymers are facilely synthesized with efficient conversation and abundant functionality. l-[4-[N,N-Bis(trimethylsilyl)-amino]phenyl]-l-phenylethylene, which is redefined as Ugi-DPE, is anionically copolymerized to synthesize the well-defined in-chain, multi-amino functionalized polystyrene (P(St/DPE-NH2 )), the backbone for the Ugi-4CR, via hydrolysis of the copolymerization (P(St/Ugi-DPE)). Subsequently, several functionalized components are facilely clicked onto P(St/DPE-NH2 ) to investigate the model reactions of the in-chain, multicomponent functionalization via the Ugi-4CR. In contrast to conventional postpolymerization modifications, this approach proceeds under mild reaction conditions without the use of a catalyst and meanwhile an efficient conversation is obtained. Finally, the modified experimental results investigated in this research show the promising potential of the combination of well-defined amino functionalized polymers and Ugi-4CR in the field of multicomponent, functionalized postpolymerization modification.
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