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Systemic Inflammation after Third Molar Removal: A Case-Control Study.

F Graziani^1,2, F D'Aiuto², S Gennai¹

¹1 Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, Italy.

Journal of Dental Research

|August 1, 2017

Summary

This summary is machine-generated.

Impacted third molars are linked to increased systemic inflammation and oxidative stress. Surgical removal of these molars reduces inflammation markers and oxidative stress indicators, showing potential systemic health benefits.

Keywords:

C-reactive protein endothelium inflammation mediators oral surgical procedures oxidative stress wisdom tooth

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Area of Science:

Oral Surgery
Systemic Inflammation Research
Metabolic Biomarker Analysis

Background:

Third molar extraction is a common dental procedure.
Limited evidence exists regarding systemic inflammation and metabolic changes in individuals with impacted third molars.
The systemic effects of surgical third molar removal require further investigation.

Purpose of the Study:

To compare systemic inflammation, vascular function, and metabolic biomarkers between individuals with impacted third molars and controls.
To evaluate the acute and short-term systemic effects of surgical third molar extraction.

Main Methods:

A case-control study involving 40 patients was conducted.
Biomarkers assessed included high-sensitive C-reactive protein, lipids, fibrinogen, oxidative stress markers (malondialdehyde), and endothelial function.
Patients with bilateral impacted/semi-impacted third molars were compared to controls without third molars.

Main Results:

Patients undergoing third molar extraction showed higher systemic inflammation, oxidative stress, and triglyceride levels compared to controls.
Post-surgery, elevated white blood cell counts, C-reactive protein, and fibrinogen were observed.
Within three months, all measured markers returned to baseline levels.
Malondialdehyde levels significantly decreased after third molar removal.

Conclusions:

Impacted or semi-impacted third molars are associated with elevated systemic inflammation.
Surgical removal of impacted third molars may offer beneficial systemic effects and serves as a model for studying acute inflammation.