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Related Concept Videos

Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

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Related Experiment Video

Updated: Jun 19, 2026

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
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Genomic approaches to accelerate cancer interception.

Jennifer Beane1, Joshua D Campbell1, Julian Lel1

  • 1Department of Medicine and BU-BMC Cancer Center, Boston University, Boston, MA, USA.

The Lancet. Oncology
|August 1, 2017
PubMed
Summary

Genomic big data approaches offer new strategies for cancer prevention and early detection. These tools, developed through multicenter collaborations, promise to revolutionize cancer interception and improve patient outcomes.

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Area of Science:

  • Oncology
  • Genomics
  • Computational Biology

Background:

  • Recent advances in targeted and immune-based therapies have improved late-stage cancer treatment.
  • A critical need exists for improved cancer prevention and early detection strategies.

Purpose of the Study:

  • To highlight emerging big data genomic approaches for cancer prevention, screening, and early detection.
  • To discuss the challenges in translating these genomic tools for clinical application.

Main Methods:

  • Leveraging advances in genomics and computational biology.
  • Analyzing big data to understand early molecular events in carcinogenesis.
  • Coordinated multicenter consortia for tool development.

Main Results:

  • Genomic approaches provide opportunities to intercept cancer development.
  • These methods have the potential to accelerate progress in early cancer detection across tumor types.

Conclusions:

  • Emerging big data genomic strategies are poised to transform cancer interception.
  • Clinical implementation of these tools requires addressing inherent challenges.