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Updated: Feb 25, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: June 30, 2013
THPdb: Database of FDA-approved peptide and protein therapeutics
Salman Sadullah Usmani1, Gursimran Bedi1, Jesse S Samuel1
1Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh, India.
Abstract:
THPdb (http://crdd.osdd.net/raghava/thpdb/) is a manually curated repository of Food and Drug Administration (FDA) approved therapeutic peptides and proteins. The information in THPdb has been compiled from 985 research publications, 70 patents and other resources like DrugBank. The current version of the database holds a total of 852 entries, providing comprehensive information on 239 US-FDA approved therapeutic peptides and proteins and their 380 drug variants. The information on each peptide and protein includes their sequences, chemical properties, composition, disease area, mode of activity, physical appearance, category or pharmacological class, pharmacodynamics, route of administration, toxicity, target of activity, etc. In addition, we have annotated the structure of most of the protein and peptides. A number of user-friendly tools have been integrated to facilitate easy browsing and data analysis. To assist scientific community, a web interface and mobile App have also been developed.
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