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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Hybridoma Technology01:31

Hybridoma Technology

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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
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Adaptive Mechanisms in Cancer Cells02:53

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
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Recent advances (2015-2016) in anticancer hybrids.

Nagaraju Kerru1, Parvesh Singh1, Neil Koorbanally1

  • 1School of Chemistry and Physics, University of KwaZulu Natal, P/Bag X54001, Westville, Durban 4000, South Africa.

European Journal of Medicinal Chemistry
|August 2, 2017
PubMed
Summary

Molecular hybridization creates novel anticancer drugs by combining multiple pharmacophores. These hybrid anticancer agents offer improved efficacy, reduced side effects, and overcome drug resistance compared to traditional therapies.

Keywords:
Anticancer hybridsCancerMechanism of actionStructure-activity relationship

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Area of Science:

  • Drug Discovery and Development
  • Medicinal Chemistry
  • Oncology

Background:

  • Cancer remains a leading cause of death globally, with existing treatments facing limitations like multidrug resistance and severe side effects.
  • Single-target therapies are often insufficient for effective cancer control.
  • Molecular hybridization, combining multiple bioactive scaffolds, presents a promising strategy to enhance drug affinity and activity.

Purpose of the Study:

  • To review recent developments (2015-2016) in anticancer hybrid drug discovery.
  • To provide insights into the structure-activity relationship (SAR) of these novel hybrids.
  • To explore the mechanisms of action for advanced anticancer hybrids.

Main Methods:

  • Literature review focusing on anticancer hybrid research from 2015-2016.
  • Analysis of molecular hybridization strategies in anticancer drug design.
  • Examination of structure-activity relationship (SAR) data for synthesized hybrids.

Main Results:

  • Hybrid anticancer drugs demonstrate potential to overcome pharmacokinetic limitations of conventional agents.
  • Key advantages include increased specificity, improved patient compliance, and reduced chemo-resistance.
  • Successful design and synthesis of novel anticancer hybrids have been documented.

Conclusions:

  • Molecular hybridization is a powerful strategy for developing next-generation anticancer therapeutics.
  • Anticancer hybrids offer a multi-pronged approach to combat cancer, addressing resistance and side effects.
  • Further research into SAR and mechanisms of action will optimize hybrid drug development.