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Transnuclear Mice with Pre-defined T Cell Receptor Specificities Against Toxoplasma gondii Obtained Via SCNT
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Published on: October 1, 2010

T cell independent Thy-1 allo-antibody response with the use of transgenic mice

K Isobe, G Kollias, A B Kolsto

    Journal of Immunology (Baltimore, Md. : 1950)
    |October 1, 1986
    PubMed

    We have introduced a mouse Thy-1.1 gene into the germline of Thy-1.2 mice. The introduced gene was shown to be expressed at very high levels in thymocytes when compared with the endogenous gene. Transgenic thymocytes were shown to evoke a higher than normal primary anti-Thy-1.1 antibody response in plaque-forming cell (PFC) assays. This result suggests that a direct quantitative interaction of the Thy-1 antigen activates the B cell response.

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