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Updated: Feb 25, 2026

Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
Frailty, body composition and nutritional status in non-institutionalised elderly
Leonel São Romão Preto1, Maria do Carmo Dias Conceição2, Telma Martins Figueiredo1
1Departamento de Enfermagem, Escola Superior de Saúde, Instituto Politécnico de Bragança, Bragança, Portugal.
Objective:
Frailty is a clinical syndrome characterized, among other signs, by involuntary weight loss and decreased muscle strength. The aim of this study was to analyse associations between frailty, body composition and nutritional status in non-institutionalised elderly people in the municipality of Alfândega (Braganza-Portugal).
Method:
Observational, prevalence and association study involving 220 elderly (mean 75.8±6.8 years of age; 68.8% women). Frailty was assessedt according to Fried criteria, body composition by bioelectrical impedance analysis and nutritional status using the Mini Nutritional Assessment Short-Form.
Results:
The prevalence of frailty was 23.6%. Frail participants had, on average, lower total muscle mass and lower segmental muscle mass (arms and legs) than pre-frail and non-frail (p <.001). From the elderly at risk of malnutrition or undernourished (n=24), the majority (n=13) had frailty syndrome. It was observed that 41.2% of the elderly with low weight were frail. This syndrome prevailed only in 17.1% of the eutrophic persons, increasing again to 22.4% in the overweight group (p <.001).
Conclusion:
The phenotypic profile of frail elderly was characterised by lower muscle mass. The results of our study suggest that both underweight and overweight may be associated with frailty. There is the need to prevent and manage frailty, not only taking into account possible treatable medical causes, but also by intervening in important pillars, such as physical activity, dietary and nutritional problems.
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