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Profilin, a Change in the Paradigm.

P Rodríguez Del Río1,2, A Díaz-Perales3,4, S Sánchez-García1,2

  • 1Allergy Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.

Journal of Investigational Allergology & Clinical Immunology
|August 2, 2017
PubMed
Summary
This summary is machine-generated.

Profilin, a common protein, is increasingly recognized as a significant allergen in pollen, latex, and food allergies. Recent findings suggest it may indicate severity and potentially be used for targeted treatments.

Keywords:
AllergenAllergyAsthmaBet v 2Food allergyImmunotherapyPhl p 12Profilin

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Area of Science:

  • Immunology
  • Allergology
  • Biochemistry

Background:

  • Profilin is a ubiquitous eukaryotic protein implicated in cross-reactivity among pollen, latex, and plant foods.
  • Traditionally considered a minor allergen, emerging evidence highlights its significant clinical relevance.

Purpose of the Study:

  • To comprehensively review the role of profilin in allergies to pollen, latex, and plant foods.
  • To re-evaluate the established understanding of profilin as a minor allergen.

Main Methods:

  • Systematic review of published literature on profilin sensitization and clinical manifestations.
  • Analysis of epidemiological data and clinical case studies.

Main Results:

  • Profilin sensitization shows a north-south gradient and is strongly linked to grass pollen and Cucurbitaceae allergies.
  • Latex profilin (Hevea brasiliensis protein 8) can indicate plant food allergy but has minimal relevance in latex allergy.
  • Sensitization impacts allergy diagnosis and immunotherapy selection; component-resolved diagnostics are useful but lack targeted treatments.

Conclusions:

  • Profilin's role in allergy requires a paradigm shift, recognizing it as a potentially significant allergen.
  • Further research is needed to clarify its clinical impact in diverse populations and develop specific therapeutic strategies.