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Updated: Feb 25, 2026
System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
Published on: April 5, 2017
In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis
Matthew B McNeil1, Devon D Dennison1, Catherine D Shelton1
1TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA.
Abstract:
Oxazolidinones are promising candidates for the treatment of Mycobacterium tuberculosis infections. We isolated linezolid-resistant strains from H37Rv (Euro-American) and HN878 (East-Asian) strains; resistance frequencies were similar in the two strains. Mutations were identified in ribosomal protein L3 (RplC) and the 23S rRNA (rrl). All mutant strains were cross resistant to sutezolid; a subset was cross resistant to chloramphenicol. Mutations in rrl led to growth impairment and decreased fitness that may limit spread in clinical settings.
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