Related Experiment Video
Updated: Feb 25, 2026

Identifying Caspases and their Motifs that Cleave Proteins During Influenza A Virus Infection
Published on: July 21, 2022
Caspase-11 Plays a Protective Role in Pulmonary Acinetobacter baumannii Infection
Wei Wang1, Yue Shao1, Shengjun Li2
1Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, China.
Abstract:
Activation of caspase-11 by some Gram-negative bacteria triggers the caspase-1/interleukin 1β (IL-1β) pathway, independent of canonical inflammasomes. Acinetobacter baumannii is a Gram-negative, conditionally pathogenic bacterium that can cause severe pulmonary infection in hospitalized patients. A. baumannii was revealed to activate canonical and noncanonical inflammasome pathways in bone marrow-derived macrophages (BMDMs). Pulmonary infection of caspase-11-/- mice with A. baumannii showed that caspase-11 deficiency impaired A. baumannii clearance, exacerbated pulmonary pathological changes, and enhanced susceptibility to A. baumannii These data indicate that the caspase-11-mediated innate immune response plays a crucial role in defending against A. baumannii.
Related Concept Videos
Caspases
Pneumonia II: Pathophysiology
The Intrinsic Apoptotic Pathway
Gene Regulation in Microbial Communities: Quorum Sensing
The Antiviral System of Bacteria and Archaea: CRISPR
Acute Respiratory Failure-II
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:

