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Lobulated Bowen's Disease with a Clear Cell Change
Dong Yoon Lee1, Ki Hwa Choi1, Su Hyun Park1
1Department of Dermatology, School of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Korea.
A novel variant of Bowen's disease, termed "lobulated Bowen's disease," presents with a cerebriform appearance and significant clear cell changes. Further research is needed to understand the clear cell changes in Bowen's disease.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Bowen's disease, an intraepidermal squamous cell carcinoma, typically presents as a scaly erythematous patch.
- Uncommon variants, including verrucous and clear cell types, have been documented.
Observation:
- A novel clinical variant of Bowen's disease with a cerebriform (brain-like) surface morphology is described.
- Histopathological examination reveals significant clear cell change in this variant.
Findings:
- The study introduces a new clinical presentation of Bowen's disease characterized by a lobulated, cerebriform appearance.
- A notable finding is the prominent clear cell change observed histopathologically, distinct from previously reported variants.
Implications:
- The proposed clinical term "lobulated Bowen's disease" aids in classifying this unique presentation.
- Elucidating the precise definition and etiopathogenesis of clear cell change in Bowen's disease is crucial for accurate diagnosis and treatment.
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