Atherogenic indices in stroke patients: A retrospective study

Area of Science:

• Cardiovascular Medicine
• Neurology
• Biochemistry

Background:

• Stroke is a leading global cause of death and disability.
• The relationship between lipid profiles and stroke risk remains inconsistently reported.
• Limited research exists on specific lipid indices in stroke patients.

Purpose of the Study:

• To investigate the association between various lipid parameters and lipid indices with stroke.
• To compare lipid profiles and indices between stroke patients and a healthy control group.

Main Methods:

• Retrospective analysis of medical records from 620 participants (290 stroke patients, 330 controls).
• Collection of baseline characteristics, lipid profiles (total cholesterol, HDLc, LDLc, triglycerides), and calculation of lipid indices (AIP, CRI-I, CRI-II, AC, non-HDLc).
• Statistical comparison of lipid parameters and indices between stroke patients and controls.

Main Results:

• Stroke patients exhibited significantly higher levels of lipid parameters and indices compared to controls.
• Castelli's Risk Index I, atherogenic coefficient, and non-HDLc were significantly associated with stroke risk.
• No significant correlation was found between hospital stay duration and lipid parameters or indices.

Conclusions:

• Elevated atherogenic lipid indices are significantly associated with stroke.
• Lipid indices like CRI-I, AC, and non-HDLc may serve as valuable indicators for stroke risk assessment.