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A human tumour model.

A P Forrest, P A Levack, U Chetty

    Lancet (London, England)
    |October 11, 1986
    PubMed
    Summary
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    This study reverses standard breast cancer treatment, administering systemic therapy before surgery for large tumors. This allows personalized treatment selection based on tumor response, improving patient outcomes.

    Area of Science:

    • Oncology
    • Medical treatment protocols

    Background:

    • Large operable breast cancers (greater than 4 cm) present management challenges.
    • Conventional treatment sequence involves mastectomy followed by systemic therapy.

    Purpose of the Study:

    • To describe a novel approach for managing large operable breast cancers.
    • To evaluate the efficacy of reversing the conventional treatment sequence.
    • To enable personalized systemic therapy selection based on treatment response.

    Main Methods:

    • Patients with large operable breast cancers underwent systemic therapy prior to mastectomy.
    • Response to individual endocrine therapy or chemotherapy regimens was measured.
    • Clinical response was correlated with histological and biochemical tumor parameters.

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    Main Results:

    • Eleven of twenty-three patients responded to endocrine treatment.
    • Twelve of thirteen patients responded to combination chemotherapy.
    • Five patients achieved a histologically complete response to combination chemotherapy.

    Conclusions:

    • Reversing the treatment sequence allows for accurate assessment of systemic therapy efficacy.
    • This approach facilitates individualized systemic therapy selection for breast cancer patients.
    • The method links clinical response to tumor characteristics for tailored treatment strategies.