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[Risk factors associated with the development of early neurological complications in purulent meningitis in a

Martha Marcela Espinoza-Oliva1, Dalia Berenice Rizo-Santos2, Rafael Díaz-Peña1

  • 1Servicio de Infectología Pediátrica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jal., México.

Gaceta Medica De Mexico
|August 2, 2017
PubMed

Insights

Pediatric purulent meningitis complications are linked to seizures, meningeal signs, and altered consciousness. Early identification of these risk factors, including turbid cerebrospinal fluid (CSF) and positive CSF culture, is crucial for timely intervention.

Area of Science:

  • Pediatric Neurology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Purulent meningitis poses a significant threat to pediatric populations, often leading to severe neurological sequelae.
  • Early identification of risk factors is critical for mitigating adverse outcomes in children with purulent meningitis.

Purpose of the Study:

  • To investigate the specific risk factors associated with the development of early neurological complications in children diagnosed with purulent meningitis.
  • To provide data that can inform clinical decision-making and improve patient management strategies.

Main Methods:

  • A case-control study was conducted involving 78 pediatric patients (one month to 16 years) with purulent meningitis.
  • Patients were categorized into two groups: cases with early neurological complications (<72 hours) and controls without such complications.
  • Data collected included clinical presentation, serum laboratory results, and cerebrospinal fluid (CSF) analysis.

Main Results:

  • Factors significantly associated with early neurological complications included: convulsive crises on admission (OR, 2.65), meningeal signs (OR, 2.73), altered state of consciousness (OR, 13.0), and need for orotracheal intubation (OR, 14.47).
  • Cerebrospinal fluid (CSF) characteristics such as turbidity (OR, 4.20) and hypoglycorrhachia (OR, 9.2) were also strongly linked to complications.
  • A positive CSF culture (OR, 16.5) was a critical indicator of increased risk for neurological complications.

Conclusions:

  • Convulsive crises, meningeal signs, altered consciousness, need for intubation, turbid CSF, hypoglycorrhachia, and positive CSF culture are key predictors of early neurological complications in pediatric purulent meningitis.
  • These findings underscore the importance of vigilant monitoring and prompt management in pediatric patients presenting with purulent meningitis.
Abstract

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